Whats your diagnosis? #1 (last updated July 10th)
A 3 week old DSH kitten died suddenly after 2 days of diarrhea.
Differential Diagnosis for Multifocal liver necrosis in a kitten:
Viral:
FIP
Bacterial:
Salmonellosis
Tularemia
Yersinia spp
Nocardia spp
E. coli
Clostridium piliforme
Protozoal:
Toxoplasma gondii
Fungal:
Histoplasmosis
Here are the histo pics:
There are multifocal areas of necrosis with very little associated inflammation in the liver. We did not see any bacteria with H&E or Giemsa stains, and we did not see fungi by H&E.
What is the next step?
Culture: Aerobic and anaerobic cultures were negative for growth.
View the answer
Filed under: What's your diagnosis? | Tagged: Feline, Hepatobiliary
i’m working on a case report having the same histopathologic situation as the pic above and it’s about a domestic cat suspected to be infected by avian influenza. i thought it could be an option in the differential diagnosis.
Reference: Vet Path 44: 261-268 (2007) : A report from Germany found multifocal marked hepatic necrosis as one of the primary lesions of HPAI infection in 3 adult cats.
oops!
the case i mentioned was one of the AFIP. we’re vetmed students studying on it. thanks for your updating of the Germany one.