Tyzzer’s Disease in a Feline

Answer: Whats your diagnosis # 1

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Multifocal hepatic necrosis

Warthin Starry Silver stain.

Clostridium piliforme is visible at the edge of necrotic areas. We also found focal transmural necrosis of the large intestine with Clostridium piliforme in the wall.

3 Responses

  1. i have found similar gross and microscopic lesions in sheep. does this disease persists in ovine species? do you have any references.

    • I have not been able to find published reports of Tyzzer’s in sheep. The 5th ed of Pathology of Domestic Animals mentions foals, calves, dogs, cats, and lab animals. I dont see why it couldn’t affect sheep.

  2. Wow! Thanks for sharing this good material and work you have done!
    Very interesting and informative too.
    Thank you very much!

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