History: A 10 year old female spayed Boxer had an acute onset of Respiratory distress and a long history of mildly elevated BUN and Creatinine that spiked at the time of presentation. Radiographs of the chest showed diffuse miliary radio-opaques lesions.
Kidneys: Hydronephrosis and pyelonephritis, bilateral.
There was clear fluid with some white flocculent material in the renal pelvis, and some obvious areas of necrosis in the cortex.
Urinary Bladder: Cystitis, Proliferative cystitis, lymphofollicular cystitis
Other possible DDX: Transitional cell carcinoma and lymphoma
There are neutrophils in many tubule lumina in the cortex and medulla.
Many Bowmans capsules are dilated, the glomerular tuft shrunken and the Bowman’s capsule is thickened and the epithelium hypertrophied.
The inflammation is a mixture of mostly plasma cells, with lymphocytes and neutrophils. The inflammation extends into muscular layer and surrounds the ureter.
Lung: The lung was diffusely mineralized and failed to collapse.
This example shows some of the mineral and plasmacytic inflammation and loss of architecture of the lung.
Other findings: Parathyroid hyperplasia and 3 large liver abscesses. The liver abscesses were so necrotic that cellular detail was lost, but we were able to see neutrophils, lymphocytes and plasma cells in the necrotic areas as well as in the surrounding normal tissue.