Lymphoma in a Llama


History: A 7 year old intact male Llama had a 3 day history of lethargy, decreased water intake and oliguria. The Llama was febrile with increased lung sounds (R>L). A CBC showed leukocytosis and pre-renal azotemia. An ultrasound showed consolidated tissue in the right thorax.

Gross Findings:

The mediastinal lymph nodes were enlarged. A large soft white mass (lymph node) measuring 15 cm x 3 cm x 3 cm was found beneath the vertebral column in the thorax.

The abdomen contained approximately 1L of clear yellow fluid.

The liver contained multifocal 3 mm to 15 mm white nodules that were slightly raised above the liver capsule and found throughout the liver parenchyma.

Liver- multifocal white nodules

Liver- multifocal white nodules

A large white infiltrative mass was present in the wall of C3 which caused a 20 cm round area of ulceration and necrosis of the mucosa of C3. The mass was adhered to C1 and the liver. The contents of C3 contained partially digested blood.

C3 adhered to the liver

C3 adhered to the liver with neoplastic infiltration

The kidneys both had multifocal 3 mm -10 mm white nodules.

Kidney- focal nodule

Kidney- multifocal nodules

The gross lesions are consistent with lymphoma, which is pretty common in Llamas.

Histopathology:

Focal area of neoplastic lymphocyte infiltration

Kidney: Focal area of neoplastic lymphocyte infiltration

Close up of neoplastic lymphocytes

Kidney: Close up of neoplastic lymphocytes

Neoplastic lymphocytes infiltrate the liver

Liver: Neoplastic lymphocytes infiltrate the liver

The immunohistochemistry did not stain well.  I am having them redone.   

Non-related findings:

The thorax contained approximately 1 L of yellow to orange clear fluid with a small amount of fibrin.

Thorax showing lungs with cranioventral consolidation

Thorax showing lungs with cranioventral consolidation and fluid

The lungs were cranioventrally consolidated and purple in color. This was diagnosed as bacterial bronchopneumonia.

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About Brian

Anatomic Pathologist, VetPath Services, Stone Ridge, NY- musculoskeletal, oral/dental, and sinonasal diseases
This entry was posted in Necropsy Cases and tagged , , , , . Bookmark the permalink.

6 Responses to Lymphoma in a Llama

  1. marwa says:

    pleas could you give me pathological picture of lymphoma in llama?

  2. Brian says:

    Histo pics uploaded, but the IHC for CD3 and CD79a did not work well so I am having them redone.

  3. Brian says:

    For a recent review of Malignnat round cell neoplasia in camelids read this paper:

    Vet Pathol 46:288–298 (2009). Malignant Round Cell Neoplasia in Llamas and Alpacas J. M. MARTIN, B. A. VALENTINE, C. K. CEBRA, R. J. BILDFELL, C. V. LO¨ HR, AND K. A. FISCHER.

    B cell tumors are most prevalent, followed by T cell, and about 25% are Primitive Malignant Round Cell Tumors.

  4. Dr. Vijay Patel says:

    Could you please send me information for differential diagnosis of haematopoietic cells?

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