Whats your diagnosis #4


Whats your diagnosis #4

History:

An 8 month old castrated male  DSH cat with weak PLR’s, slow menace,  circling to the left, and then progressed to ataxia, and he had a distended
bladder.
Gross findings: No gross abnormalities
Histopathology:

Brain:  There are multifocal to coalescing areas of spongiosis,
necrosis and edema in both grey and white matter with large numbers of
lymphocytes, macrophages, and variable numbers of neutrophils and
multinucleated giant cells.  Cellular infiltrates center mostly
around blood vessels within the cerebrum and brainstem.  There are
numerous blood vessels surrounded by large numbers of lymphocytes
and plasma cells with some histiocytic cells.
Brain: Perivascular histiocytic infiltrates with few neutrophils
Brain: Coalescing perivascular and parenchymal histiocytes with neutrophils, lymphocytes, and plasma cells
Brain: Perivascular lymphocytic cuffing
Brain: There are many multinucleated cells within the inflammatory infiltrates
Morphologic Diagnosis:

Brain: Granulomatous and necrotizing encephalitis, multifocal to
coalescing, severe
Differential diagnoses:
Rabies
FIP
FIV
FeLV
Fungal infection
Bartonella henselae
Amoebic encephalitis
Toxoplasma
HPAI
Idiopathic
Others?
More to come…
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About Brian

Anatomic Pathologist, VetPath Services, Stone Ridge, NY- musculoskeletal, oral/dental, and sinonasal diseases
This entry was posted in What's your diagnosis? and tagged , . Bookmark the permalink.

One Response to Whats your diagnosis #4

  1. stefan says:

    I guess you can rule out the rabies. If the cat was castrated probably it was also vaccinated. The Babes-Negri bodies would probably be present in the neurons if it were rabies. The symptoms presented seem to point in another direction than rabies. I’ve never seen circling in any description of rabies symptoms and in rabies, as far as I know death is by progressive paralysis.
    I will try to have a look around for the other diseases that you have there and I will post comments hopefully by the end of next week.
    Until then, take care and have a good week!!!

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