Experimental Chronic Wasting Disease (CWD) in theExperimental Inoculation: Develop CWD when injected PrP from deer into cerebrum but do not develop CWD if PrP given orally-Clinical signs: Polyphagia, somnolence, piloerection, lordosis and ataxia– Microscopic lesions: Spongiosis of neurophil in basal ganglia, thalamus, midbrain and pons -Exception: Perivascular PrP aggregates or plaques are absent in ferrets but present in cervids.

Identification of Group 1 Coronavirus Antigen in Multisystemic Granulomatous Lesions in Ferrets (Mustela putorius furo): Group 1 includes human coronavirus strain 229E, porcine TGE virus, canine coronavirus, porcine epidemic diarrhoea virus, and ferret enteric coronavirus. Four main types of lesions were observed: diffuse granulomatous inflammation on serosal surfaces; granulomas with areas of necrosis; granulomas without necrosis; and granulomas with neutrophils.

Cystic Renal Disease in the Domestic Ferret. Vol 58, No 2. primary polycystic disease consisting of either polycystic kidney disease affecting renal tubules or, more commonly, glomerulocystic kidney disease. Secondary polycystic lesions were identified in 11 ferrets (20%), and 12 ferrets

(22%) exhibited focal or isolated tubular cysts only as an incidental necropsy finding. Ferrets with secondary renal cysts associated with other developmental anomalies, mesangial glomerulopathy, or end-stage kidney disease had hyperphosphatemia and elevated BUN in comparison with those with primary cystic disease and elevated BUN compared with those without renal lesions.

High-throughput Immunophenotyping of 43 Ferret Lymphomas Using Tissue Microarray Technology. Vet Pathol 44:196–203 (2007).  The results of this study confirmed previously published results suggesting specific cross-reactivity of the applied IHC markers (CD3, CD79a, Ki67) with ferret lymphoma tissue. Other IHC markers (CD45Ro, bcl2, bcl10, MUM1, CD30, vimentin) were also expressed in subsets of the included ferret lymphomas.   TMA technology was useful for rapid and accurate analysis of protein expression in large archival cohorts of ferret lymphoma cases.

Myofasciitis in the Domestic Ferret.  Vet Pathol 44:25–38 (2007). young ferrets, Gross lesions -atrophy of skeletal muscle; red and white mottling and dilatation of the esophagus; and splenomegaly. Histologically-suppurative to pyogranulomatous myositis in the esophagus, heart, limbs, body wall, head, and lumbar regions. Myeloid hyperplasia of spleen and/or bone marrow also is a prominent feature. Ultrastructural lesions include mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands.

Subcutaneous Neoplasms of the Ventral Abdomen with Features of Adrenocortical Tumors in Two Ferrets. Vet Pathol 44:951–955 (2007).  neoplasms were composed of islands of polygonal cells separated by interlacing streams of spindloid cells reminiscent of ferret adrenocortical tumors with smooth muscle proliferation. immunohistochemically, the polygonal cells demonstrated strong cytoplasmic reactivity for inhibin and weak cytoplasmic reactivity for pancytokeratin and S-100 protein. Spindloid cells demonstrated strong cytoplasmic reactivity for alpha smooth muscle actin, muscle-specific actin, desmin, and glial fibrillary–associated protein. Ultrastructurally, the polygonal cells contained numerous intracytoplasmic clear vacuoles, mitochondria, scant rough endoplasmic reticulum, and few intermediate filaments.  suggestive of adrenocortical tumors with smooth muscle proliferation, but cannot be differentiated from an ovarian gonadal stromal tumor.

Clinicopathologic Features of a Systemic Coronavirus-Associated Disease Resembling Feline Infectious Peritonitis in the Domestic Ferret Vet Path 2008 Mar: Grossly, whitish nodules on mesentery, lymph nodes, visceral peritoneum, liver, kidneys, spleen, and lungs. Microscopically, pyogranulomatous inflammation was seen. IHC positive for coronavirus antigen using monoclonal antibody FIPV3-70. Two diseases caused by coronaviruses have been described in ferrets: severe acute respiratory syndrome (SARS) and epizootic catarrhal enteritis (ECE). Wet form like in cats was not seen.

Cytochrome b5  Expression in Gonadectomy-induced Adrenocortical Neoplasms of the Domestic Ferret (Mustela putorius furo). Vet Pathol 45:439–442 (2008) July. Normal  adrenocortical  cells  lacked  cyt  b5,  which  may  account  for  the  low  production  of  adrenal androgens in healthy ferrets. Other markers characteristic of gonadal somatic cells, such as luteinizing hormone receptor, aromatase, and GATA4, were coexpressed with cyt b5  in some of the tumors. We concluded  that cyt b5  is  upregulated during gonadectomy-induced  adrenocortical  neoplasia.

Pathology of Experimental SARS Coronavirus Infection in Cats and Ferrets.  Vet Pathol 45:551–562 (2008). All infected cats and ferrets had diffuse alveolar damage associated with SARS-CoV antigen expression.  SARS-CoV antigen expression occurred mainly in type I and II pneumocytes and serous cells of tracheo-bronchial submucosal glands of cats and in type II pneumocytes of ferrets. ACE2 expression occurred mainly in type I and II pneumocytes, tracheo-bronchial goblet cells, serous epithelial cells of tracheo-bronchial submucosal glands in cats, and type II pneumocytes and serous epithelial cells of tracheo-bronchial submucosal glands in ferrets. syncytia and hyaline membranes were not observed.

Laboratory Findings, Histopathology, and Immunophenotype of Lymphoma in Domestic Ferrets.  Vet Pathol 45:663–673 (2008). Tumors involved the viscera of the abdominal cavity, thoracic cavity; the skin; or the viscera. Microscopically, all tumors had diffuse architecture. Diffuse T-cell lymphoma > anaplastic large T-cell lymphoma >, anaplastic large B-cell lymphoma > diffuse large B-cell lymphoma > and Hodgkin-like lymphoma. frequently associated with anemia and, in some cases, may be chemosensitive, resulting in relatively long survival times.

Naturally occurring influenza infection in a ferret (Mustela putorius furo) colony.  J Vet Diagn Invest 21:527–530 (2009). bronchointerstitial  pneumonia with necrotizing bronchiolitis. Influenza A virus was detected. homology  to  contemporary  reassortant  H1N1  swine  influenza  viruses.

Bacterial Diskospondylitis Associated with Posterior Paresis/Paralysis in North American Farmed Mink: Posterior paresis/paralysis in farmed mink is responsible for significant morbidity and mortality. 32of the 40 affected animals had an isolated vertebral lesion chr by bone lysis and proliferation centered on an intervertebral disk space in the midthoracic area with suppurative inflammation and gram-positive cocci. Streptococcus sp. was commonly isolated from the intervertebral disk. We conclude that posterior paresis/paralysis in farmed mink is associated with bacterial diskospondylitis, likely occurring secondary to bacteremia/septic

Detection of Group C Rotavirus in Juvenile Ferrets (Mustela putorius furo) with Diarrhea by Reverse Transcription Polymerase Chain Reaction: Sequencing and Analysis of the Complete Coding Region of the VP6 Gene. Vet Pathol 46:985–991 (2009). Histologically, small  intestines  exhibited  acute superficial  atrophic  enteritis.  Transmission  electron microscopy  of  the  small  intestine  showed  rotavirus-like particles  within  apical  vacuoles.  Reverse transcription  polymerase  chain  reaction  (RT-PCR)  was  negative  for  group  A  rotavirus.

A KIT-positive gastrointestinal stromal tumor in a ferret (Mustela putorius furo).  J Vet Diagn Invest 21:915–917 (2009). A 1.5-year-old, neutered, male ferret (Mustela putorius furo) was presented with sudden lethargy, anorexia, and diarrhea. Clinical and radiographic examinations revealed an intra-abdominal mass. An explorative laparotomy was performed. A neoplasm, located in the ileum wall, was submitted for histopathologic examination. The tumor consisted of weakly eosinophilic spindle cells arranged in a compact pattern with haphazardly interlacing bundles. Neoplastic cells labeled positively for KIT (cluster of differentiation 117, stem cell factor receptor) and vimentin. Based on histologic and immunohistologic results, this tumor was diagnosed as a gastrointestinal stromal tumor. Results suggest that this ferret tumor shares strong similarities with the canine and human counterparts.

Neuropathologic features of Aleutian disease in farmed mink in Ireland and molecular characterization of Aleutian mink disease virus detected in brain tissues. J Vet Diagn Invest 22:101–105 (2010). Neuropathologic  features  of  nonsuppurative meningoencephalitis were common.  The meningoencephalitis was characterized by infiltrates of lymphocytes and plasma  cells,  which  were  present  in  meninges,  perivascular  spaces,  and  the  brain  parenchyma.  Fibrinoid necrotizing arteritis was seen in 11 mink brain

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